Retention structures, systems and related methods are generally provided. Certain embodiments provide the stay structure to a subject (e.g., a patient) (e.g., orally) so that the stay structure is maintained at an internal location of the subject for a certain time (e.g., at least about 24 hours) <； / RTI >； The retention structure may in some cases be a retention structure. In some embodiments, the structures and systems described herein provide a high level of loading of the active material (e.g., therapeutic), high stability of the active material and / or structure in the acidic environment, And / or in physiological environment (e.g., intestinal environment), and / or in a biological environment (e.g., intestinal environment) until it is delivered to the desired internal cavity And one or more substances configured for rapid dissolution / degradation in response to a chemical irritant (e.g., ingestion of a solution that induces rapid dissolution / degradation). In certain embodiments, the structure is required to stay above the material that is configured for controlled release of therapeutic, diagnostic, and / or enhancing agents, but may be controlled to control the time at which the structure exits the stomach, And / or a structural material configured for adjustable dissolution / dissolution. For example, in certain embodiments, the retention structure comprises a first elastic element, a second element configured to release an active agent (e.g., a therapeutic agent), and optionally a linker. In some such embodiments, the linker may be disassembled and configured so that the retention structure is broken after a predetermined period of time and separated and released from the internal position of the object. [Representative figure] 1e체류 구조체, 시스템 및 관련 방법이 일반적으로 제공된다. 특정 실시양태는 체류 구조체가 방출 전 특정 시간 (예를 들어, 적어도 약 24시간) 동안 대상체의 내부 위치에서 유지되도록, 체류 구조체를 대상체 (예를 들어, 환자)에게 (예를 들어, 경구로) 투여하는 것을 포함한다. 체류 구조체는 일부 경우에 위 체류 구조체일 수 있다. 일부 실시양태에서, 본원에 기재된 구조체 및 시스템은 높
