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Phenolic derivatives, and their pharmaceutical or cosmetic use
专利权人:
Galderma Research & Development
发明人:
POINSARD, Cédric,COLLETTE, Pascal,MAUVAIS, Pascale,LINGET, Jean-Michel,RETHORE, Sandrine
申请号:
ES10808916
公开号:
ES2674398T3
申请日:
2010.12.22
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compounds of the formula (1): ** Formula ** in which: - R 1 represents a halogen, a methyl, ethyl, isopropyl, trifluoromethyl, nitrile, nitro, methoxy, ethoxy, isopropoxy, thiomethyl, thioethyl or thioisopropyl group; - R2 represents a hydrogen atom; - R3 represents a hydrogen atom or a C1-6 alkyl group; R4, R5, R6, R7 are identical or different and represent either a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C1-6 alkyloxy, -S (O) 1-C1-6 alkyl group, C 1-6 fluoroalkyl, C 1-6 fluoroalkyloxy, - (CH 2) C 3-9 cycloalkyl, -C 1-6 alkyl-OH, - (CH 2) C 1-6 alkyloxy, - (CH 2) C 1-6 fluoroalkyl, - (CH2) C1-6 fluoroalkyl, CORa, CN, NR10R11, or a halogen or a phenyl or heteroaryl group containing either a) of 1 to 4 nitrogen atoms or b) an oxygen or sulfur atom and 1 or 2 nitrogen atoms, the phenyl and heteroaryl groups possibly being substituted with one to three identical or different Rc groups, - Ra and Rf are identical or different and represent a C1-6 alkyl, C1-6 alkyloxy or NR12R13 group, - Rc represents a halogen, a C1-6 alkyl group, C3-7 cycloalkyl, C1-6 alkyloxy, -S (O) k-C1-6 alkyl, C1-6 fluoroalkyl, C1-6 fluoroalkyloxy, - (CH2) g -C3-7 cycloalkyl, OH, - (CH2) g-C3-7 cycloalkyl, -C 1-6 alkyl-OH, - (CH2) g-alkyl C1-6 oxy, - (CH2) g- C1-6 fluoroalkyl, - (CH2) wO-C1-6 fluoroalkyl, CORf, CN, or NR14R15, - R10, R11, R12, R13, R14 and R15 are identical or different and represent a hydrogen atom, a C1-6 alkyl, C3-7 cycloalkyl, - (CH2) h C3-7 cycloalkyl or - (CH2) h-C1-6 fluoroalkyl group, optionally groups R10 and R11 can form with the nitrogen atom that carries them a heterocycle such as: azetidine, pyrrolidine, piperidine, azepane, morpholine or piperazine, eventually groups R12 and R13 can form with the nitrogen atom that carries them a heterocycle, such as: azetidine, pyrrolidine, piperidine, azepane, morpholine or piperazine, possibly groups R14 and R15 can form with the nitrogen atom that carries them a heterocycle, such as: azetidine, pyrrolidine, piperidine, az
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