The invention of porous tricalcium phosphate granules based method and the method of functional bone graft material using the same of such, a method of preparing a porous tricalcium phosphate based granules according to the invention without the use of a pore precursor, the dispersion medium, an organic solvent, while rotating the mixer, with a blade, the addition of tricalcium phosphate-based powder in the tricalcium phosphate-based slurry repeating the steps to form a tricalcium phosphate-based granules, characterized in that for adjusting the size of the tricalcium phosphate-based granules. In addition, functional bone grafting material of the manufacturing method according to the invention combines the pores of the porous tricalcium phosphate-based bone morphogenetic protein by immersing the granules in a porous tricalcium phosphate-based bone granules to form a protein solution prepared by the method of the present invention It is characterized by freeze-drying. Porous tricalcium phosphate-based method of producing granules of the present invention may be the process is simple, creating a porous tricalcium phosphate based granules is harmless to the human body, in a manufacturing process (in-situ) the size of the porous tricalcium phosphate based granules in It can be easily adjusted. Further, the bone graft material production method of the present invention is to minimize damage to the bone morphogenetic protein, specifically, an inert protein to reduce the potential of the water by completely removing water by freeze-drying, the growth of bacteria can be suppressed.본 발명은 다공성 인산삼칼슘계 과립의 제조 방법 및 이를 이용한 기능성 골이식재의 제조방법에 관한 것으로서, 본 발명에 따른 다공성 인산삼칼슘계 과립의 제조방법은 기공 전구체, 분산매, 유기용매를 사용하지 않고, 칼날을 가진 믹서를 회전시키면서 인산삼칼슘계 슬러리에 인산삼칼슘계 분말을 첨가하는 단계를 반복하여 인산삼칼슘계 과립을 형성시키고, 인산삼칼슘계 과립의 크기를 조절하는 것을 특징으로 한다. 또한, 본 발명에 따른 기능성 골이식재의 제조방법은 본 발명의 제조방법으로 제조한 다공성 인산삼칼슘계 과립을 골형성 단백질 용액에 침지하여 골형성 단백질을 다공성 인산삼칼슘계 과립의 기공에 결합시키고 이를 동결건조시키는 것을 특징으로 한다. 본 발명의 다공성 인산삼칼슘계 과립의 제조방법은 공정이 간편하고 인체에 무
