INTERNALIZING ERBB2 ANTIBODIES

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专利权人:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人:

MARKS, JAMES D.,POUL, MARIE ALIX

申请号：

CA2326377

公开号：

CA2326377C

申请日:

1999.04.23

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

This invention provides novel erbB2-binding internalizing antibodies. Theantibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and,upon binding, are readily internalized into the cell bearing the c-erbB2marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached toone or more effector molecules are also provided.

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