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Systems and methods for determining optimum patient-specific antibody dose for tumor targeting
专利权人:
Memorial Sloan Kettering Cancer Center
发明人:
Cheal, Sarah M.,Larson, Steven M.,Osborne, Joseph Reginald,Fung, Edward Komin,Ulmert, David,Zanzonico, Pat B.
申请号:
AU2016268038
公开号:
AU2016268038A1
申请日:
2016.05.19
申请国别(地区):
AU
年份:
2017
代理人:
摘要:
The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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