Disclosed is an operation device for unilateral pedicle vertebroplasty, comprising a pilot sleeve (1), a bone drill (2) and a bone cement injection channel (3). A conical head (4) is provided at the top end of the pilot sleeve (1) and a through hole (5) for a guide needle to pass through is provided at the conical head (4) along the axial direction thereof. The subface of the conical head at the inner side of the pilot sleeve (1) is a cambered slope surface (6). An oval circular hole (7) is provided at a position of the side wall of the pilot sleeve (1) opposite to the cambered slope surface (6). The bone drill (2) comprises a push rod (11) and a cardan drill (12), wherein the cardan drill (12) is connected to the push rod (11) through an elastic rod piece (13) which is bendable in any direction. The cardan drill (12) can pass through the oval circular hole (7) and enter a predetermined position in the vertebral body under the guide of the cambered slope surface (6) after entering the pilot sleeve (1). The bone cement injection channel (3) comprises a bone cement injection sleeve (14) and a hose (15) which is bendable in any direction connected at the top end thereof, wherein an elastic polyethylene guide wire is provided inside the hose (15) and can pass through the oval circular hole (7) and enter a predetermined position in the vertebral body under the guide of the cambered slope surface (6) after entering the pilot sleeve (1). The operation device is simple to operate, easy to hold and has a good acceptance by doctors.Linvention concerne un dispositif de fonctionnement pour vertébroplastie pédiculaire unilatérale, comprenant une douille pilote (1), un foret à os (2), et un canal dinjection de ciment osseux (3). Une tête conique (4) est fournie à lextrémité supérieure de la douille pilote (1) et un trou de passage (5) pour le passage dune aiguille guide est fourni au niveau de la tête conique (4) le long de la direction axiale de celle-ci. La surface de la tête c