PROBLEM TO BE SOLVED: To provide development of compounds especially for preventing and treating adhesion in the fields of pharmacological, clinical and experimental agents and veterinary medicine, and pharmaceutical compositions comprising a sufficient amount of one or more of the above compounds, a pharmaceutically acceptable carrier, a diluent or an excipient.SOLUTION: Provided is a method for preventing and/or treating non human animal's diseases having a possibility of formation and/or growth of adhesion, comprising administering an effective amount of a p38MAP kinase inhibitor to the abdominal cavity of a non-human animal. Also provided is a pharmaceutical composition comprising a p38MAP kinase inhibitor being a natural or synthetic water soluble polymer of which side chain is derived from 4-(4-fluorophenyl)-2-(4-methylsulfinyl-phenyl)-5-(4-pyridyl)-H-imidazole or 4-{(4-fluoro or 3-iodine)-phenyl}-2-(4-methylsulfinyl-phenyl)-5-(4-pyridyl)-1H-imidazole.SELECTED DRAWING: None【課題】薬学的、臨床的及び実験的な医薬及び獣医学の分野に関し、特に癒着の予防及び治療のための化合物を開発すること、並びに十分な量の１又はそれ以上の上記化合物及び薬学的に許容される担体、希釈剤又は賦形剤を含む医薬組成物の提供。【解決手段】癒着形成及び/又は癒着進展の可能性がある非ヒト動物の疾患又は病状の予防及び/又は治療の方法であって、有効量のＰ３８ＭＡＰキナーゼ阻害剤を非ヒト動物の腹腔内に投与する方法。ｐ３８ＭＡＰキナーゼ阻外剤が４－（４－フルオロフェニル）－２－（４－メチルスルフィニル－フェニル）－５－（４－ピリジル）－Ｈ－イミダゾール又は４－｛（４－フルオロ又は３－ヨウ素）－フェニル｝－２－（４－メチルスルフィニル－フェニル）－５－（４ピリジル）－１Ｈ－イミダゾール由来の基を側鎖とする天然又は合成の水溶性ポリマーである医薬組成物。【選択図】なし
