Anti-DEspR monoclonal antibody targeted therapy and imaging for cancer and stroke

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专利权人:

Trustees of Boston University

发明人:

Ruiz-Opazo, Nelson,Herrera, Victoria L.M.

申请号：

AU2016311265

公开号：

AU2016311265A1

申请日:

2016.08.24

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or

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