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High surface-area lyophilized compositions comprising arsenic for oral administration in patients
专利权人:
Orsenix Holdings BV
发明人:
Krishna Vaddi,Kumar Kurumaddali
申请号:
US16299214
公开号:
US10653628B2
申请日:
2019.03.12
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention relates to treating malignancies such as tumors or cancers by orally administering lyophilized compositions comprising arsenic to a subject in such need. Malignancies include various hematological malignancies, such as acute myeloid leukemia (AML) including acute promyelocytic leukemia (APL), myelodysplastic syndrome (MDS), multiple myeloma (MM) and lymphomas and solid tumors including glioblastoma multiforme and breast cancer. Arsenic treatment has shown great promise in the treatment of several cancers but requires daily intravenous (IV) administration. This invention relates to a novel formulation comprising a lyophilized compositions comprising arsenic. As a result, the formulation facilitates a systemic bioavailability comparable to that of intravenous (IV) administration of arsenic trioxide currently practiced. The present invention also relates to a method for lyophilizing the arsenic trioxide, preparing the oral formulation comprising lyophilized compositions comprising arsenic, and a method for treating a subject with malignancies using the oral formulation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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