The present invention discloses a nourishing smoothing anti-wrinkle hand cream, which is prepared by the following steps of (1) adding ginseng aqueous solution, sodium hyaluronate, EDTA-2NA and allantoin into a stirring pan, heating and slowly stirring until the temperature rises to 80, stopping heating, and continuously stirring till a mixture of the raw materials is completely resolved and transparent (2) continuously stirring, and adding NAOH after the temperature drops to 40 (3) continuously stirring, adding ceramide, D-panthenol, water-soluble jojoba oil, argireline, VE, lubrajel, amino-peptide, EGF, lipoic acid lipid nanoparticles, nanometer vitamin A, coenzyme Q10, horse chestnut extract, biosaccharide gum-4, pentanedioland centella asiatica extract and (4) after the temperature drops to 30, adding antiallergic agent, and then discharging. Clinical experiments prove that the present invention has apparent unique effects for nourishing, easing and repairing hand skin wrinkles after being used for a long term, and has no side effects.
