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PHARMACEUTICAL COMPOSITION CONTAINING OCTREOTIDE MICROPARTICLES
专利权人:
НОВАРТИС АГ (CH)
发明人:
ЛАМБЕР Оливье (FR),АУСБОРН Михаэль (DE),ПЕТЕРСЕН Хольгер (DE),ЛЁФФЛЕР Рольф (DE),БОННИ Жан-Даньель (CH)
申请号:
RU2010144614/15
公开号:
RU2010144614A
申请日:
2010.11.01
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition comprising octreotide acetate microparticles made from a linear copolymer of lactide with glycolide, in which the polymer contains less than 1% silicone oil or heptane, preferably without silicone oil or heptane. ! 2. A pharmaceutical composition comprising octreotide acetate microparticles made from a linear copolymer of lactide with glycolide, in a mixture or in association with a diluent comprising a nonionic surfactant. ! 3. The pharmaceutical composition according to claim 1 or 2, further comprising a substance that prevents agglomeration. ! 4. A method of producing microparticles of octreotide acetate, comprising the steps of:! a) dissolving or dispersing octreotide acetate in methylene chloride containing a dissolved linear copolymer of lactide with glycolide, to obtain a dispersion; ! b) combining said dispersion with an effective amount of a continuous working medium to obtain an emulsion that contains said continuous working medium and microdroplets comprising said octreotide acetate, said solvent and said linear copolymer of lactide with glycolide; and! C) immediately after the formation of the specified emulsion of a single addition of the specified emulsion to an effective amount of an extracting medium for extracting the specified solvent from these microdroplets with obtaining these microparticles. ! 5. A method of producing octreotide acetate microparticles by the method of repeated emulsification, the improvement of which includes the stages:! a) dissolving octreotide acetate in water, emulsifying an aqueous solution of octreotide acetate in methylene chloride,1. Фармацевтическая композиция, включающая микрочастицы октреотидацетата, изготовленные из линейного сополимера лактида с гликолидом, в которой полимер содержит менее 1% силиконового масла или гептана, предпочтительно, не содержащего силиконового масла или гептана. ! 2. Фармацевтическая композиция, включающая микрочастицы октреотидацетата, изготовленные из лине
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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