Wenge ZHONG,Stephen HITCHCOCK,Vinod F. PATEL,Michael CROGHAN,Thomas DINEEN,Scott HARRIED,Daniel HORNE,Ted JUDD,Matthew KALLER,Charles KREIMAN,Patricia LOPEZ,Holger MONENSCHEIN,Thomas NGUYEN,Matthew WE
申请号：
US13410201
公开号：
US20120220583A1
申请日:
2012.03.01
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase activity and for the treatment of diseases, including Alzheimers disease (AD) and related CNS conditions, mediated thereby. In one embodiment, the compounds have a general Formula Ior Formula IIwherein R1a-1c, B, R3-5 and W of Formula I, and R1a-1c, R2-5, A1-4, W, X, Z, m and n of Formula II are defined herein. The invention further provides compounds of Formula III and IV and sub-Formulas II-A-II-D and III-A-III-D. The compounds may be used in pharmaceutical compositions for treating, prophylactically or therapeutically, disorders related to the activity of beta-secretase protein, including without limitation, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions.
