PARK, CHAN HEE,박찬희,LEE, SANG HWI,이상휘,IM, JUN HWAN,임준환,LEE, SOON OK,이순옥,KIM, JUNG SOOK,김정숙,PARK, HEON KYU,박헌규,YUN, JEE HUN,윤지훈,KO, KWANG SEOK,고광석,KIM, BYUNG HO,김병호,KONG, MIN JUNG,공민정,MOON, HYUNG JO,문형조,PARK, CHAN HEEKR,LEE, SANG HWIKR,IM, JUN HWANKR,LEE, SOON OKKR,KIM, JUNG SOOKKR,PARK, HEON KYUKR,YUN, JEE HUNKR,KO, KWANG SEOKKR,KIM, BYUNG HOKR,KONG, MIN JUNGKR,공민
申请号：
KR1020150128025
公开号：
KR1020160066490A
申请日:
2015.09.10
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a heterocyclic derivative represented by chemical formula 1, a pharmaceutically acceptable salt thereof or a stereoisomer thereof. The heterocyclic derivative, or a pharmaceutically acceptable salt or stereoisomer thereof has an excellent effect of inhibiting activation of proteins. Therefore, a pharmaceutical composition comprising the heterocyclic derivative, or a pharmaceutically acceptable salt or stereoisomer thereof is useful for treating or preventing diseases related to activation of STAT3 protein. In chemical formula 1, X_1, X_2, X_3, X_4, Y, Z, Rx, A, B, R_c, R_N, L_B, R_A, R_B, p and q are the same as defined in the specification.하기 화학식 1의 헤테로사이클 유도체, 이의 약학적으로 허용가능한 염 또는 입체이성체는 STAT3 단백질의 활성화 억제 효과가 우수하므로, 이를 함유하는 약학적 조성물은 STAT3 단백질의 활성화와 관련된 질환을 치료 또는 예방하는데 유용하다:[화학식 1]상기 식에서, X1, X2, X3, X4, Y, Z, Rx, A, B, Rc, RN, LB, RA, RB, p 및 q는 명세서 본문에서 정의한 바와 같다.
