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USE OF CYTOKINE-RELEASING, BIODEGRADABLE PARTICLES IN HYALURONIC ACID FOR THE TREATMENT OF CARTILAGE DEFECTS, IN PARTICULAR OF OSTEOARTHROSIS
专利权人:
Michael Sittinger;Kristin Andreas;Jochen Ringe
发明人:
Kristin Andreas,Jochen Ringe,Michael Sittinger
申请号:
US13990643
公开号:
US20130337074A1
申请日:
2011.11.30
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The present invention relates to a composition comprising, or consisting of 2-50 mg/ml hyaluronic acid, 0.1-500 mg/ml of biodegradable particles with an average mean particle diameter of 1 nm-500 μm, 1 pg/ml-10 μg/ml cytokines, where the concentrations specified are based in each case on the total volume (w/v) of the composition and where the cytokines are enclosed in the biodegradable particles, and to their use in the treatment of cartilage defects, for example traumatic cartilage defects or osteoarthrosis.
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