ФЕВОЛА Майкл Дж. (US),САН Фрэнк С. (US),ЙОРК Стейси Е. (US)
申请号：
RU2012155329/04
公开号：
RU2012155329A
申请日:
2012.12.19
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula I: (I) where Z is a polyglycerol nodular structure containing at least 3 adjacent glycerol residues； Nu are independently selected nucleophilic groups directly connected to Z； d is the number of nucleophilic groups directly linked to Z, and ranges from 2 to 21； L is an independently selected linking group connecting Z to Hphob； Hphob is an independently selected hydrophobic moiety containing from 6 to 30 carbon atoms； a represents the number of Hphob groups associated with the nodal structure of Z, each with the help of L, is from zero to 10； L is an independently selected linking group connecting Z to the cationic group -RN - [(R) (R) (Hphob)]； R represents independently selected linear or branched alkylene (-CH- to -CH-) or monohydroxyalkylene (-CH (OH) to -CH (OH) -)； N represents a nitrogen atom； R represents an independently selected alkyl group containing from 1 to 4 carbon atoms (from CH to CH) or a hydrogen atom； R is an independently selected alkyl group containing containing from 1 to 4 carbon atoms (from CH to CH) or a hydrogen atom, or an independently selected hydrophobic fragment； Hphob is an independently selected hydrophobic fragment containing from 6 to 30 carbon atoms； X represents an anionic counterion or is absent； b represents the number of groups ( RN - [(R) (R) (Hphob)]) associated with the nodal structure of Z, each with the help of L, is from zero to 10； L is an independently selected linking group connecting Z to the cationic group -RN - [( R) (R) (R)]； R is an independently selected linear1. Соединение формулы I:(I)гдеZ представляет собой полиглицериновую узловую структуру, содержащую по меньшей мере 3 смежных глицериновых остатка；Nu представляют собой независимо выбранные нуклеофильные группы, непосредственно соединенные с Z；d представляет собой число нуклеофильных групп, непосредственно связанных с Z, и составляет от 2 до 21；Lпредставляет собой независимо выбранную связующую группу, соединяющую Z с Hphob；Hphobп
