Carl F. Ware,Carl De Trez,Michael Croft,Timothy C. Cheung,Ian R. Humphreys,Karen G. Potter,Christopher A. Benedict,Mitchell Kronenberg,Marcos W. Steinberg
申请号：
US12482426
公开号：
US08349320B2
申请日:
2009.06.10
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and acts as a molecular switch that modulates T cell activation by propagating positive signals from the TNF related ligand, LIGHT (p30, TNFSF14), or inhibitory signals through the immunoglobulin superfamily member, B and T lymphocyte attenuator (BTLA). A novel binding site for BTLA is disclosed, located in cysteine-rich domain-1 of HVEM. BTLA binding site on HVEM overlaps with the binding site for the Herpes Simplex virus-1 envelope glycoprotein D (gD), but is distinct from where LIGHT binds, yet gD inhibits the binding of both ligands. A BTLA activating protein present in human cytomegalovirus is identified as UL144. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation.
