The invention relates to a combination which is typically a composition such as a medicament and which is particularly suited for topical administration. The combination is useful in the prophylaxis and/or treatment of a range of diseases, including skin diseases such as psoriasis, eczema, dermatitis, as well as other diseases including gum diseases, shingles, joint pain. In particular the combination of the invention includes an extract of green lipped mussel and honey.Linvention concerne une association qui est généralement une composition telle quun médicament et qui est particulièrement appropriée pour une administration topique. Lassociation est utile dans la prophylaxie et/ou le traitement de diverses maladies, y compris des maladies de la peau telles que le psoriasis, leczéma, la dermatite, ainsi que dautres maladies, y compris des maladies gingivales, le zona, une douleur articulaire. En particulier, lassociation selon linvention comprend un extrait de moule verte et de miel.