AOtot 524 524 giver 520 ) 508 , .520 -522 518 5kb 516 -504 512 526 512 FIG. 11 1-1 1-1 C•1 O O C•1 00 O 1-1 C•1 C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 November 2018 (15.11.2018) WIPO I PCT on! olollm °nolo No oimIE (10) International Publication Number WO 2018/209021 Al (51) International Patent Classification: A61F 2/24 (2006.01) A61L 27/50 (2006.01) A61L 27/06 (2006.01) A61B 17/34 (2006.01) (21) International Application Number: PCT/US2018/031959 (22) International Filing Date: 10 May 2018 (10.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/504,389 10 May 2017 (10.05.2017) US 62/571,552 12 October 2017 (12.10.2017) US 62/659,253 18 April 2018 (18.04.2018) US 15/973,892 08 May 2018 (08.05.2018) US (71) Applicant: EDWARDS LIFESCIENCES CORPO- RATION [US/US]； One Edwards Way, Irvine, CA 92614 (US). (72) Inventors: MARR, Devin, H.； Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). DELGADO, Sergio； Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). DIXON, Eric, Robert； Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). TAYLOR, David, M.； Edwards Lifesciences, One Edwards Way, Le- gal Department, Irvine, CA 92614 (US). METCHIK, Ash- er, L.； Edwards Lifesciences, One Edwards Way, Legal De- partment, Irvine, CA 92614 (US). WINSTON, Matthew, T.； Edwards Lifesciences, One Edwards Way, Legal De- partment, Irvine, CA 92614 (US). STEARNS, Grant, Matthew； Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). SOK, Sam； Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). NGUYEN, Tam, Van； Edwards Life- sciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). KWON, Rhayoung； Edwards Lifesciences, One Edwards Way, Legal Department, Irv
