Provided are compositions comprising opioid antagonists, such as naltrexone naloxone, or nalmefene, or their pharmaceutically acceptable salts, and their use for treating scleroderma, including systemic sclerosis.L'invention concerne des compositions comprenant des agonistes opioïdes, tels que la naltrexone, la naloxone ou le nalmefène, ou leurs sels pharmaceutiquement acceptables, et leur utilisation dans le traitement de la sclérodermie, telle que la sclérodermie systémique.