589411 Provided is a chimeric single VL domain antibody comprising a human VL domain segment, a human diversity heavy (DH) domain segment, a human JL domain segment, and a non-human heavy chain C region, wherein the nonhuman heavy chain C region comprises a hinge, a CH2, and a CH3 domain segment and is substantially or completely devoid of a CH1 domain segment. The antibody can be used to treat cancer, graft versus host disease, cardiovascular disease and associated disorders, neurological diseases and disorders, autoimmune and inflammatory disorders, allergies and pathogenic infections.
