The Board of Trustees of the Leland Stanford Junior University
发明人:
Isabella A. Graef,Mamoun M. Alhamadsheh
申请号：
US16363625
公开号：
US20200016098A1
申请日:
2019.03.25
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggregate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
