Philippe Patrick MONNIER,Nardos G. TASSEW,Yuriy BAGLAENKO
申请号：
US15762497
公开号：
US20180250361A1
申请日:
2016.09.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed herein are methods and compositions for increasing and decreasing the permeability of the blood brain barrier for the treatment of diseases and conditions and to facilitate the delivery of agents to the brain, as well as methods and compositions for promoting re-myelination and preventing de-myelination. Compositions include RGMa, soluble RGMa, and functional fragments and variants thereof, RGMc, soluble RGMc, and functional fragments and variants thereof, and Neogenin peptides including 4Ig.
