DERIVADOS DO ÁCIDO 4-(INDOL-7- ILCARBONILAMINOMETIL)CICLO-HEXANOCARBOXÍLICO COMO ANTAGONISTAS DE RECEPTORES EP4, ÚTEIS NO TRATAMENTO DE INSUFICIÊNCIA RENAL CRÓNICA OU DE NEFROPATIA DIABÉTICA
[Problems] A compound, which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating chronic renal failure and/or diabetic nephropathy, is provided. [Solving Means] The present inventors have conducted extensive studies on a compound having an EP4 receptor antagonistic activity, and confirmed that the amide compound of the present invention has an EP4 receptor antagonistic activity, thereby completing the present invention. The amide compound of the present invention has an EP4 receptor antagonistic activity, and can be used as an active ingredient of a pharmaceutical composition for preventing and/or treating various EP4-related diseases, for example, chronic renal failure and/or diabetic nephropathy, and the like.
