STABILIZED POLYMERIC THIOL REAGENTS

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专利权人:

NEKTAR THERAPEUTICS AL; CORPORATION

发明人:

KOZLOWSKI, ANTONI,MCMANUS, SAMUEL P.

申请号：

CA2591233

公开号：

CA2591233C

申请日:

2005.12.21

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y-S-W]x,, where POLY is a water soluble polymer Y is a hydrocarbon~basedspacer group, x is 1 to 25, and S-W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer.Also disclosed are conjugates of such polymeric reagents with pharmaceuticallyrelevant molecules, and methods of their formation and use.

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