МЁРФИ Эндрю Дж. (US),СТИВЕНС Шон (US),РАТИНАМ Чожавендан (US),ЭЙНОН Элизабет (US),МАНЦ Маркус (CH),ФЛАВЕЛЛ Ричард (US),ЯНКОПУЛОС Джордж Д. (US)
申请号：
RU2013142043/10
公开号：
RU2013142043A
申请日:
2012.02.14
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A humanized M-CSF mouse, comprising: a nucleic acid sequence encoding a human M-CSF protein and operably linked to a promoter of the mouse M-CSF gene. 2. A humanized M-CSF mouse according to claim 1, characterized in that the mouse contains two copies of the nucleic acid sequence. The humanized M-CSF mouse according to claim 1, characterized in that the nucleic acid sequence is operably linked to the endogenous mouse M-CSF promoter at the mouse M-CSF locus. A humanized M-CSF mouse according to claim 1, characterized in that the mouse contains a null mutation of at least one mouse M-CSF allele. The humanized M-CSF mouse according to claim 4, characterized in that the null mutation is a deletion of exons 2-9 of the mouse M-CSF. The humanized M-CSF mouse according to claim 1, characterized in that the mouse is homozygous for the Rag2.7 null mutation. The humanized M-CSF mouse according to claim 6, characterized in that the mouse is homozygous for the null mutation of IL2rg. 8. A humanized M-CSF mouse according to claim 1, characterized in that the mouse contains human cells. The humanized M-CSF mouse of claim 8, wherein the human cells are hematopoietic cells. The humanized M-CSF mouse according to claim 9, characterized in that the mouse is infected with a human pathogen. A murine model of the human hematopoietic system, comprising: 2 null mutations of Rag2； 2 null mutations of IL2rg； a nucleic acid sequence encoding a human M-CSF protein operably linked to the promoter of the mouse M-CSF gene； and human hematopoietic cells. 12. The mouse model according to claim 11, characterized in that the nucleic acid sequence is functionally linked to the endogenous promoter M-C1. Гуманизированная М-CSF мышь, содержащая:нуклеиновокислотную последовательность, кодирующую человеческий M-CSF белок и функционально связанную с промотором мышиного гена M-CSF.2. Гуманизированная M-CSF мышь по п.1, отличающаяся тем, что мышь содержит две копии нуклеиновокислотной последовательности.3.
