William McGhee,James Blackledge,Margaret Grapperhaus
申请号：
US14208324
公开号：
US20140271822A1
申请日:
2014.03.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides compositions for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid, and a taxane. The PEG-lipid constitutes from about 2 to about 8 mol % of the lipids in the liposome. The taxane is docetaxel esterified at the 2′-O position with a heterocyclyl-(C2-5alkanoic acid). Methods for preparation of liposomal taxanes and treatment of cancer with liposomal taxanes are also disclosed.
