A device for treating a carpal tunnel syndrome comprises: (a) a brace configured for at least partially receiving a patient's hand; (b) displaceable support members mounted on the first member and spaced apart from each other and configured for supporting the patient's palm at areas adjacent to first and fifth metacarpal bones the patient's hand; and (c) a pressing member mounted on the second member and configured for adjustable pressure on dorsum of the patient's hand; The two displaceable support members and pressing member are mountable symmetrically to each other on palm and dorsum of the patient's hand to be received. The device comprises a generator of mechanical vibrations mounted between the displaceable support members. The vibrator is configured to apply the mechanical vibration in an area of carpal tunnel of the patient's hand.