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Saturated nitrogen and N-acylated heterocycles potentiating the activity of an active antibiotic against mycobacteria
专利权人:
Universite de Droit et de la Sante de Lille 2
发明人:
Willand, Nicolas,Deprez, Benoit,Baulard, Alain,Brodin, Priscille,Flipo, Marion,Maingot, Lucie
申请号:
AU2013366503
公开号:
AU2013366503B2
申请日:
2013.12.20
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The present invention concerns a compound of general formula (I) in which n = 0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from phenyl and optionally substituted benzyl, and the heterocycles having 6 vertices comprising one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a drug, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.
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