Provided is a pharmaceutical composition capable of alleviating or treating constipation symptoms by increasing colorectal movement, through directly delivering mosapride or pharmaceutically acceptable salt thereof, which has been used as a gastrointestinal exercise modulator through oral administration, to the large intestine. The composition according to the present invention is a constipation treatment agent which is directly administered to the large intestine, has no side effects such as headache, and has an excellent bowel movement improving effect.COPYRIGHT KIPO 2020기존에 경구 투여를 통하여 위장관 운동 조절제로 사용되어 왔던 모사프리드 또는 이의 약제학적으로 허용되는 염을 대장으로 직접 전달하여 대장운동을 증가시킴으로써 변비 증상을 개선하거나 치료할 수 있는 약제학적 조성물을 제공한다.
