Ayelet Chajut;Christine Esau;Eric G. Marcusson;C. Frank Bennett;Noga Yerushalmi
发明人:
C. Frank Bennett,Ayelet Chajut,Christine Esau,Eric G. Marcusson,Noga Yerushalmi
申请号：
US13481105
公开号：
US20120295962A1
申请日:
2012.05.25
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are methods for the treatment of liver cancer. These methods encompass the administration of a compound comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Also provided herein are compositions for the treatment of liver cancer. Such compositions include compounds comprising a modified oligonucleotide, wherein the modified oligonucleotide is targeted to a miRNA. Certain miRNAs have been identified as overexpressed in liver cancer, such as, for example, hepatocellular carcinoma, and are thus selected for targeting by modified oligonucleotides. Further, certain miRNAs have been identified as overexpressed in hepatocellular carcinoma cells exposed to dioxin, and are thus selected for targeting by modified oligonucleotides. Antisense inhibition of certain of these miRNAs has been found to inhibit cell proliferation and induce apoptosis.
