A series of monoquarternary piperazium salts including a structure of a formula I or II are provided. In formula I or II, R1, Ra, RX and Xaare as defined in the specification. The monoquarternary piperazium salt of KMUP or piperazine disclosed in the present invention is characterized by being presented in a pro-drug form and having various pharmaceutical functions.本發明係提供如式(I)或式(II)之哌嗪基團複合鹽類,其中R1、Ra、RX與Xa如說明書中之定義。本發明揭示KMUP類或piperazine之四級銨哌嗪基團之新製程,呈現前藥型以及多態樣醫療功能。