N-(6-(((2R,3S)-3,4-dihydroxy butan-2-yl)oxy)-2-((4-fluoro benzyl)thio)pyrimidin-4-yl)-3-methylazetidine-1-sulfonamide (compound 4), a known chemokine modulator, in combination with colchicine is useful in the treatment of diseases/conditions in which modulation of chemokine receptor activity, interleukin-1 (IL-1) activity, and/or myeloperoxidase (MPO) activity is beneficial. In particular, provided herein are compositions and methods for the treatment and prevention of such diseases/conditions.Compound 4本發明係關於一種N-(6-(((2R,3S)-3,4-二羥基丁烷-2-基)氧基)-2-((4-氟苄基)硫基)嘧啶-4-基)-3-甲基氮雜環丁烷-1-磺醯胺(化合物4)，一種已知趨化因子調節劑，其與秋水仙鹼組合可用於治療其中可因調節趨化因子受體活性、介白素-1 (IL-1)活性及/或髓過氧化物酶(MPO)活性而受益的疾病/病狀。特定言之，本文中提供治療及預防此等疾病/病狀之組合物及方法。化合物4
