The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.本發明係關於選擇性抑制葡萄糖轉運體1(GLUT1)之化合物、製備該等化合物之方法、包含該等化合物之醫藥組合物及組合、該等化合物用於製造用於治療或預防疾病之醫藥組合物之用途以及適用於製備該等化合物之中間化合物。