Said M. Sebti,Andrew D. Hamilton,James Turkson,Richard Jove
申请号：
US12480376
公开号：
US08153596B2
申请日:
2009.06.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific STAT isoform homo-dimerization. The peptidomimetic probes of STAT1 function, described herein, provide the means to preferentially inhibit STAT1 over STAT3 through the exploration of the C-terminus.
