DONG-EUI UNIVERSITY INDUSTRY-ACADEMIC COOPERATIONFOUNDATION;DONG-EUI UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;동의대학교 산학협력단;I S FOOD CO., LTD.;(주)아이에스푸드
发明人:
KIM, JEONG HWAN,김정환,NAM, SOO WAN,남수완,KIM, BYUNG WOO,김병우,KWON, HYUN JU,권현주,KIM, SE WON,김세원,KIM, YUCK YONG,김육용,YU, KI HWAN,유기환,KIM, JEONG HWANKR,NAM, SOO WANKR,KIM, BYUNG WOOKR,KWON, HYUN JUKR,KIM, SE WONKR,KIM, YUCK YONGKR,YU, KI HWANKR
申请号：
KR1020130056580
公开号：
KR1020140136261A
申请日:
2013.05.20
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a composition comprising a mixture of Eucommia ulmoides, Citrus paradise, and Ecklonia cava as an active ingredient. The mixture of Eucommia ulmoides, Citrus paradise, and Ecklonia cava extracts of the present invention inhibits CDK1 and CDK2 gene expression, adipocyte fatty acid binding protein (AP) gene and a peroxisome proliferator-activated receptor-&gamma； (PPAR-&gamma；) gene expression, and proliferation and differentiation of preadipocyte cells, wherein CDK1 and CDK2 are transcriptional activators associated with cell proliferation； and AP and PPAR-&gamma； are transcriptional activators for an adipocyte formation. Thus, the mixture of Eucommia ulmoides, Citrus paradise, and Ecklonia cava extracts of the present invention can be usefully applied to prevention and treatment of obesity.본 발명은 두충, 자몽 및 감태 혼합물을 유효 성분으로 포함하는 조성물에 관한 것이다.본 발명의 두충, 자몽, 및 감태의 혼합 추출물은 세포 증식 관련 전사 활성인자인 CDK1과 CDK2 유전자의 발현을 억제하고, 지방세포형성 전사 활성인자인 AP(adipocyte fatty acid binding protein) 및 PPAR-γ(peroxisome proliferator-activated receptor-γ) 유전자의 발현을 억제하며, 지방전구세포의 증식 및 분화를 억제하고, 비만의 예방 및 치료에 유용하게 이용할 수 있다.
