Various approaches for microbubble-enhanced ultrasound treatment of target tissue include retrieving a treatment plan stored in memory； causing administration of an exogenous agent in accordance with the treatment plan； causing, in accordance with the treatment plan, an ultrasound transducer to transmit ultrasound waves to the target tissue and generate a focus therein in the presence of administered exogenous agent； receiving, from a monitoring system, a measured parameter value indicating a treatment condition in response to administration of the exogenous agent and transmission of the ultrasound waves during treatment； and adjusting the treatment plan based at least in part on the measured parameter value.
