The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease, or the symptoms associated with, or related to a gastrointestinal disorder or disease in a subject in need thereof. In one aspect, the present invention provides a pharmaceutical composition comprising a proton pump inhibiting agent and a buffering agent for oral administration and ingestion by a subject. Upon administration, the composition contacts the gastric fluid of the stomach and increases the gastric fluid pH of the stomach to a pH that substantially prevents or inhibits acid degradation of the proton pump inhibiting agent in the gastric fluid and allows a measurable serum concentration of the proton pump inhibiting agent to be absorbed into the blood serum of the subject.本發明係針對在有需要之病患中治療、預防或降低發展胃腸病症或疾病之危險或伴隨著或相關於胃腸病症或疾病之病徵之方法、套件、組合及組合物。一方面，本發明係提供一種醫藥組合物，其包含質子泵抑制劑與緩衝劑，供病患口服投藥與攝食。在投藥時，此組合物係接觸胃部之胃流體，並增加胃部之胃流體pH值至實質上預防或抑制質子泵抑制劑在胃流體中酸降解之pH值，並允許可度量血清濃度之質子泵抑制劑被吸收至病患之血清中。
