Hyunah Choo,Youngjae Kim,Jihye Seong,Ghil Soo Nam,Yong Seo Cho
申请号：
US15738225
公开号：
US10435408B2
申请日:
2017.11.06
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Azepine derivatives acting on 5-HT7 receptors and pharmaceutically acceptable salts thereof are disclosed. The azepine derivatives and the pharmaceutically acceptable salts thereof have high binding affinities for and high antagonistic activities on 5-HT7 receptors. Due to these advantages, the azepine derivatives and the pharmaceutically acceptable salts thereof can be applied to therapeutic or prophylactic agents for central nervous system diseases, such as depression, migraine, anxiety, pain, inflammatory pain, neuropathic pain, body temperature dysregulation, biorhythm dysregulation, sleep disturbance, and smooth muscle diseases where 5-HT7 receptors antagonistic activity is required.
