In some examples, a method of adjusting a cardiovascular medication administration protocol for a subject includes receiving heart contractility surrogate information, obtained from a sensor configured to sense information about a heart of the subject, during a specified acute time period following an initiation or change in medication administration to the subject, determining, using a comparator circuit, whether the heart contractility surrogate information indicates an occurrence of at least a specified change in heart contractility during the specified acute time period following the initiation or change in medication administration to the subject, and adjusting the medication administration protocol using the determination of whether the heart contractility surrogate information indicates the occurrence of at least the specified change in heart contractility during the specified acute time period following the initiation or change in medication administration to the subject.
