Karen G. Carrasquillo,Anthony P. Adamis,Joan W. Miller,Evangelos S. Gragoudas
申请号：
US13247458
公开号：
US20120201859A1
申请日:
2011.09.28
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such as the eye. In addition, the invention provides methods for making such formulations, and methods of using such formulations to deliver an aptamer to a preselected locus in a mammal. In particular, the invention provides a method for delivering the aptamer to an eye for the treatment of an ocular disorder, for example, age-related macular degeneration.
