The invention relates to Chinese medicinal composition granules and a preparation method thereof. The Chinese medicinal composition granules comprise the following ruptured powder in part by weight: 3 to 18 parts of American ginseng ruptured powder, 1 to 24 parts of pseudo-ginseng ruptured powder, 6 to 36 parts of dendrobium ruptured powder, and 9 to 45 parts of root of red-rooted salvia ruptured powder, wherein the granularity D90 of the ruptured powder is between 5 and 75 mu m. The invention also provides a method for preparing the Chinese medicinal composition granules. The method comprises the following steps of: uniformly mixing the American ginseng ruptured powder, pseudo-ginseng ruptured powder, dendrobium ruptured powder, and root of red-rooted salvia ruptured powder of which the D90 is between 5 and 75 mu m preparing a soft material by adopting aqueous ethanol at the concentration of over 20 vol percent and after granulating by using a granulator with 10 to 30 meshes, drying and finishing the granules to obtain the Chinese medicinal composition granules. The Chinese medicinal composition granules are applied to preventing and regulating human cardiac-cerebral vascular system diseases and sub-health state such as weak immunity and fatigability, have the obvious advantages of high medical effect, high quality uniformity, convenient carrying and administration, safety, reliability, and the like, and can meet the requirement on modern fast-paced lifestyle.