PROBLEM TO BE SOLVED: To provide a therapeutic polypeptide with a prolonged half-life while retaining high pharmacological effectiveness for inducing hemostasis in hemophilia patients.SOLUTION: According to the present invention, there is provided a polypeptide comprising at least one to three carboxy terminal peptides (CTP) of chorionic gonadotropin bound to the carboxy terminus of a coagulation factor, and a polynucleotide encoding it. There is also provided a pharmaceutical composition comprising the polypeptide and polynucleotide, and method for using it. There is further provided a use method in which the CTP is not bound to the amino terminus of the coagulation factor, the coagulation factor is not a signal peptide, the polypeptide has coagulant activity, and the coagulation factor is Factor VII (FVII) or Activated Factor VIIa (FVIIa).SELECTED DRAWING: Figure 10【課題】血友病患者における止血を誘導するための高い薬理学的有効性を保持しながら、その半減期を延長させた治療的ポリペプチドの提供。【解決手段】凝固因子のカルボキシ末端に結合した少な１～３個の絨毛性ゴナドトロピンのカルボキシ末端ペプチド（ＣＴＰ）を含むポリペプチド、及びそれをコードするポリヌクレオチド。前記ポリペプチド及びポリヌクレオチドを含む医薬組成物、ならびにそれらを用いる方法。前記凝固因子のアミノ末端には前記ＣＴＰが結合しておらず、前記凝固因子がシグナルペプチドと有さず、前記ポリペプチドが凝固活性を有し、かつ前記凝固因子が、第ＶＩＩ因子（ＦＶＩＩ）又は活性化第ＶＩＩａ因子（ＦＶＩＩａ）である使用方法。【選択図】図１０
