SYSTEMES, COMPOSITIONS ET METHODES DE TRANSPLANTATION ET TRAITEMENT D'ETATS AU MOYEN D'UNE COMPOSITION RENFERMANT UN TYPE SAUVAGE OU UN VARIANT DU POLYPEPTIDE A2M OU UNE PORTION DE CELUI-CI
HANNA, LEWIS,LAUGHLIN, JOHN DAVID,BROWNING, SHAWN ROBERT
申请号：
CA2922806
公开号：
CA2922806A1
申请日:
2014.08.28
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds.
