Methods for increasing DISC1 in a subject with schizophrenia or bipolar disorder by an antagonist inhibiting DISC1 binding to FBXW7

• 收藏
• 分享

专利权人:

The University Court of the University of Glasgow

发明人:

George Baillie

申请号：

US15025273

公开号：

US09981005B2

申请日:

2014.09.29

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The invention relates to the finding that turnover of DISC1 (Disrupted in schizophrenia 1) is mediated by the F-box-containing protein FBXW7 (F-box/WD repeat-containing protein 7). The sequence within DISC1 that binds to FBXW7 and targets DISC1 for turnover by the ubiquitin-proteasome system is identified. The invention provides antagonists that inhibit this interaction and methods of using these antagonists to decrease DISC1 turnover, for example in treatment of neuropsychiatric disorders, as well as methods of identifying new antagonists.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/