Christopher James SLOEY,Sekhar KANAPURAM,Huanchun CUI,Chio Mui CHAN,Elaheh BINABAJI
申请号：
US15902775
公开号：
US20180237501A1
申请日:
2018.02.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced viscosities when compared to formulations lacking N-acetyl arginine. Provided herein are also methods of formulating such compositions that are advantageous in that they conserve certain components. Such formulations comprising PCSK9-binding polypeptides can be administered to patients to treat and/or prevent PCSK9-related diseases, conditions, and disorders.
