A kit comprising: (a) one or more oral dosage forms； and (b) means for facilitating compliance using a safe and effective amount of a pharmaceutical composition, wherein the one or more oral dosage forms comprises the safe and effective amount of a pharmaceutical composition comprising: (a) from about 1 mg to about 500 mg of a bisphosphonate which is selected from the group consisting of risedronate and acids, salts, and esters thereof； (b) from about 10 mg to about 1000 mg of a chelating agent； and (c) a delayed release mechanism to deliver the bisphosphonate and the chelating agent in the lower gastrointestinal tract.
