The present invention relates to skin care formulations including octapeptide complexes. A preferred embodiment of the skin care formulation is a multi-active serum, which treats numerous skin problems associated with environmental exposure and aging. In one aspect, the multi-serum may be formulated for treatment of facial skin, and may optionally be applied as a mask. In another aspect, the multi-active serum may be formulated specifically for the treatment of delicate skin in the under-eye area of the fact. This embodiment of the invention may be applied as an under eye mask. In yet another aspect, the invention provides a method of manufacturing skin care formulations including octapeptide complexes.