To provide methods of treating cancer.SOLUTION: The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor, and methods for use thereof, including methods of treating or delaying progression of conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for treating or delaying progression of cancer. Preferably a method in which the PD-1 binding antagonist is an antibody, MDX-1106, Merck 3745, CT-011, or AMP-224.SELECTED DRAWING: Figure 8【課題】がんの治療方法の提供。【解決手段】ＰＤ-１軸結合アンタゴニストとＭＥＫ阻害剤を含む併用療法と、癌の治療又は進行の遅延のための腫瘍免疫原性の増大のような免疫原性の増大が所望される症状を治療又はその進行の遅延する方法を含むその使用方法。好ましくは、ＰＤ－１結合アンタゴニストが、抗体、ＭＤＸ－１１０６、メルク３７４５、ＣＴ－０１１又はＡＭＰ－２２４である、方法。【選択図】図８
