LOUIS S. CHUPAK,MIN DING,SCOTT W. MARTIN,XIAOFAN ZHENG,PIYASENA HEWAWASAM,TIMOTHY P. CONNOLLY,NINGNING XU,KAP YEUNG,JULIANG SUN - ZHU,DAVID R. LANGLEY,DANIEL J. TENNEY,PAUL MICHAEL SCOLA
申请号：
ARP150101104
公开号：
AR100059A1
申请日:
2015.04.13
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Requirement 1: a compound having the properties of formula (1),O salts are pharmaceutically acceptable, where m is 0.1 o r 2； R 1 is selected from hydrogen, - (ch832225x and - (ch832245ar)； n is 1, 2, 3 or 4； X is selected from - ch832323；-CF8323,CN -CO R-C (O) NHOR y pirrolidonilo R es H o C alquilo Ar se selecciona de benzodioxanilo indazolilo isoquinolinilo isoxazolilo naftilo oxadiazolilo fenilo piridinilo pirimidinilo y quinolinilo en donde cada anillo se sustituye opcionalmente con 1 2 3 4 sustituyentes independientemente seleccionados de C alcoxi C alcoxicarbonilo C alcoxicarbonilamino C alquilo (C -(CH 83222) qqqqqqu22；； c8321； select from complex Equations (2) and (3),where Y is selected from cyano, chlorine and methyl； Rq is selected from hydrogen, C₁₋₃ alkyl and benzyl； R³ is selected from the compounds of the group of formulas (4) where Rᶻ is selected from C₁₋₃ alkyl, C₁₋₃ alkylsulfonyl C₁₋₃ alkyl, C₁₋₃ alkylsulfoxyl-C₁₋₃ alkyl, amido-C₁₋₃ alkyl, amino-C₁₋₄ alkyl, carboxy-C₁₋₃ alkyl, cyano-C₁₋₃ alkyl, dimethylamido-C dime alkyl, dimethylamino-C₁₋₄ alkyl, halo-C₁₋₃ alkyl, hydroxy-C₁₋₃ alkyl, C₁ ₋₃ alkylsulfanyl-C₁₋₃ alkyl, pyridinyl-C₁₋₃ alkyl, tetrazolyl-C₁₋₃ alkyl, imidazolyl-C₁₋₃ alkyl,wherein the imidazole is optionally substituted with methyl or a benzyl group, phenyl-C₁₋₃ alkyl, where the phenyl is optionally substituted with cyano, methyl or hydroxy, thiazolyl-C₁₋₃ alkyl； R⁶ is selected from hydrogen, benzyl and methyl； each R⁶ is independently selected from hydrogen and methyl； R⁷ is selected from hydrogen, C₁₋₃ alkyl and benzyl； o is 1 or 2； X is CH or N； p is 0 or 1； Rᵃ is hydroxy； and Rᵇ is selected from hydrogen, benzyl and methyl； or R³ and Rq, together with the nitrogen atom to which they are attached, form a ring selected from the group of formulas (5)；S is 0 or 1； Z is 1, 2 or 3； r831222 is selected from hidroxi y-nhsoe83222；R8313 selected hydrogen y-co8322； h； R1 83044 selected from halogen and hydrogen Xi； R1 selected from trifluoroide,
