Daniel J. Finley,John W. Hanna,Nathaniel A. Hathaway,Randall W. King,Byung-Hoon Lee
申请号：
US14022337
公开号：
US09201073B2
申请日:
2013.09.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to methods and compositions for enhancing proteasome activity in a cell. The methods and compositions for enhancing the activity of the proteasome in cells modulate the activity of Ubp6 (yeast) or Usp14 (human), an endogenous inhibitor of the proteasome. The methods and compositions partially or completely reduce the inhibitory activity of Usp14 on a proteasome, thereby specifically enhancing the protein-degradation activity of the proteasome. The invention also provides methods of screening to identify inhibitors of Ubp6, Usp14, and/or both Ubp6 and Usp14.
